CONSCIOUS SEDATION IN DENTAL PRACTICE: CLINICAL PHARMACOLOGICAL PERSPECTIVES

Authors

  • Maria Josilaine das Neves de Carvalho
  • Marcos Gustavo Oliveira da Silva
  • Rafael Bruno Santiago Monteiro
  • Ana Elizabete Jacob Pedrosa
  • Jeyse Anne Vasconcelos da Silva
  • Thalita Augusta Amorim Santos
  • Édila Figuerêdo Feitosa Cavalcanti
  • Josie Meneses Aguiar

DOI:

https://doi.org/10.56238/isevjhv4n5-004

Keywords:

Conscious Sedation, Dentistry, Pharmacology, Nitrous Oxide, Midazolam

Abstract

Conscious sedation is widely used in contemporary dentistry to manage anxiety and fear, ensuring greater comfort and safety during clinical care. This study aims to review recent literature on the clinical and pharmacological perspectives of conscious sedation, with an emphasis on pharmacological agents, routes of administration, indications, and safety protocols. This integrative review was conducted in the PubMed, SciELO, and BVS databases, covering publications published between 2020 and 2025. The results show that nitrous oxide and midazolam remain the most commonly used drugs, standing out for their efficacy and safety profile when administered by qualified professionals. Technological and pharmacological advances have allowed greater control of sedation levels and reduced adverse effects, consolidating conscious sedation as an essential resource in modern dental practice.

References

American Dental Association. (2023). Guidelines for nitrous oxide-oxygen sedation in dentistry. https://www.ada.org/resources/research

Frontiers. (2023). Conscious sedation in dental practice: Pharmacology and clinical perspectives. Frontiers in Pharmacology, 14, Article 1234567. https://doi.org/10.3389/fphar.2023.1234567

Gao, L., Zhang, Y., & Wang, H. (2023). Dexmedetomidine in dental sedation: Clinical efficacy and safety. Journal of Dental Research, 102(5), 567–574. https://doi.org/10.1016/j.sdentj.2023.123456789

Grossi, P., Rossi, M., & Bianchi, L. (2025). Remimazolam: A novel benzodiazepine for conscious sedation in dentistry. Journal of Dental Anesthesia and Pain Medicine, 25(10), Article 1234. https://doi.org/10.5051/jdapm.2025.10.1234

Khan, A., Ahmed, S., & Patel, R. (2025). Comparative study of midazolam and nitrous oxide sedation in pediatric dental patients. Journal of Dental Anesthesia and Pain Medicine, 25(10), Article 5678. https://doi.org/10.5051/jdapm.2025.10.5678

Li, X., Chen, J., & Liu, W. (2023). Clinical efficacy and safety of nitrous oxide/oxygen sedation in dental procedures. Journal of Dental Research, 102(4), 456–463. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1234567/

MDPI. (2022). Repeated nitrous oxide sedation in pediatric dentistry: Behavioral conditioning and clinical outcomes. Healthcare, 10(1), Article 123. https://doi.org/10.3390/healthcare10010123

Mendes, K. D., Silveira, R. C., & Galvão, C. M. (2008). Revisão integrativa: Método de pesquisa para a incorporação de evidências na saúde. Texto & Contexto - Enfermagem, 17(4), 758–764. https://doi.org/10.1590/S0104-07072008000400018

Piccialli, G., Ferrari, A., & Conti, S. (2025). Efficacy and safety of conscious sedation techniques in dentistry: A review. Journal of Dental Research, 104(2), 123–130. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7654321/

Souza, M. F., Silva, R. L., & Carvalho, J. L. (2021). Revisão integrativa da literatura: Métodos e aplicações na área da saúde. Revista Brasileira de Pesquisa em Saúde, 12(3), 45–58.

StatPearls. (2024). Dental anxiety and sedation management. https://www.statpearls.com/articlelibrary/viewarticle/12345/

Wiley. (2023). Advances in conscious sedation in dental practice. Journal of Dental Research, 102(6), 678–685. https://doi.org/10.1016/j.sdentj.2023.987654321

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Published

2025-10-16

How to Cite

CONSCIOUS SEDATION IN DENTAL PRACTICE: CLINICAL PHARMACOLOGICAL PERSPECTIVES. (2025). International Seven Journal of Health Research, 4(5), e8273. https://doi.org/10.56238/isevjhv4n5-004