MULTIDISCIPLINARY TREATMENT OF BONE SARCOMAS: OSTEOSARCOMA, CHONDROSARCOMA, AND EWING SARCOMA
DOI:
https://doi.org/10.56238/isevjhv4n6-002Keywords:
Osteosarcoma, Chondrosarcoma, Ewing Sarcoma, Targeted Therapy, EWS-FLI1, Biomarkers, ImmunotherapyAbstract
Bone sarcomas, rare and aggressive neoplasms such as osteosarcoma, chondrosarcoma, and Ewing sarcoma, require a multidisciplinary and stratified oncologic and orthopedic approach. This review synthesizes evidence published between 2015 and 2025, addressing the surgical gold standard, neoadjuvant chemotherapy (MAP and VAC/IE regimens), radiotherapy, immune checkpoint inhibitor therapies (ICIs), and the emerging role of circulating molecular biomarkers (ctDNA). Recent studies highlight the importance of morphofunctional imaging characterization (CT and PET-CT) and molecular signatures (e.g., EWS-FLI1 translocation) to guide precise therapeutic decisions.
References
Parkin, D. M., Clayton, D., Black, R. J., Masuyer, E., Friedl, H. P., Ivanov, E., Sinnaeve, J., Tzvetansky, C. G., Geryk, E., Storm, H. H., Rahu, M., Pukkala, E., Bernard, J. L., Carli, P. M., L'Héritier, V., Hatton, F., Swerdlow, A. J., Kennedy, K. A., Langmark, F., … Young, J. L. (1996). Childhood leukaemia in Europe after Chernobyl: 5 year follow-up. British Journal of Cancer, 73(8), 1006–1012.
Antunes, R. S., Garcia, J. J., Freitas, D. M., Perez, A. S., Andrade, M. G. S., & Marchionni, A. M. (2024). Clinical and imaginological manifestations of cherubism: A case report. International Seven Journal of Health Research, 3(1), 1–8.
Contemporary Surgical Approaches in Managing Laryngeal Chondrosarcoma. (s.d.). PubMed.
Estudo descobre mutação responsável por cancro ósseo agressivo em crianças. (2025, janeiro). Observador.
ResultMed. (2025). Sarcoma treatment 2025 Israel – Innovations and trials.
Avanços no tratamento do osteossarcoma. (2024). Revista Brasileira de Cancerologia.
Systemic treatment for primary malignant sarcomas. (2022). Frontiers in Oncology.
Emerging approaches to aggressive bone sarcomas. (2023). ASCO Publications.
Evaluation of the efficacy and safety of immunotherapy in sarcomas. (2024). Frontiers in Immunology.
Genomics and therapeutic vulnerabilities of primary bone tumors. (2020). PMC.
Evaluating circulating biomarkers for diagnosis and prognosis in pediatric sarcomas. (2024). PMC.
