International Seven Journal of Multidisciplinary
type: channel
description: The International Seven Multidisciplinary Journal (ISMJ) ISSN- 2764-9547 is a journal dedicated to the publication of articles and studies related to all areas of knowledge, with bilingual publications in English, Spanish and Portuguese.
publisher: Isabele de Souza Carvalho
language: en
publication name: International Seven Journal of Multidisciplinary
issn: 2764-9547
items: 3D PRINTING AS A STRATEGIC TECHNOLOGY OF INDUSTRY 4.0: A SYSTEMATIC REVIEW OF THE MAIN APPLICATION AREAS
items: THERAPEUTIC MANAGEMENT OF COLORECTAL CANCER IN THE ELDERLY: BALANCING EFFICACY AND TOLERABILITY
items: TREATMENT OF PEDIATRIC CELIAC DISEASE: MONITORING GROWTH AND DEVELOPMENT
items: THERAPEUTIC MANAGEMENT OF DYSTHYMIA (PERSISTENT DEPRESSIVE DISORDER): LONG-TERM STRATEGIES AND REMISSION
items: THERAPEUTIC MANAGEMENT OF ACUTE TRAUMATIC BRAIN INJURY: RESUSCITATION AND NEUROPROTECTION PROTOCOLS
items: THERAPEUTIC MANAGEMENT OF MENOPAUSE: HORMONAL APPROACH AND NON-HORMONAL ALTERNATIVES
items: THERAPEUTIC MANAGEMENT OF VASOSPASTIC ANGINA: STABILIZATION STRATEGIES AND ANTITHROMBOTIC THERAPY
items: MAXILLARY SINUS LIFT TECHNIQUES: INDICATIONS AND CRITERIA FOR REHABILITATION OF ATROPHIC MAXILLAE
items: THERAPEUTIC MANAGEMENT OF CHILDHOOD GINGIVITIS: MECHANICAL BIOFILM CONTROL PROTOCOLS AND ORAL HYGIENE
items: THERAPEUTIC MANAGEMENT OF ODONTOGENIC KERATOCYST: FROM SIMPLE ENUCLEATION TO ADJUVANT TECHNIQUES
items: BONE RECONSTRUCTION TECHNIQUES WITH AUTOGENOUS GRAFTS: INDICATIONS AND DONOR SITE SELECTION CRITERIA
items: ENVIRONMENTAL RISK MANAGEMENT IN THE WORKPLACE: IDENTIFICATION AND MITIGATION OF ENVIRONMENTAL HAZARDS AFFECTING WORKER HEALTH AND SAFETY
items: PROJECT MANAGEMENT IN FOREIGN TRADE SOFTWARE IMPLEMENTATIONS: APPLICATION OF THE PMI METHODOLOGY IN REGULATED ENVIRONMENTS
items: ENVIRONMENTAL IMPACTS OF DIFFUSE LOGISTICS IN URBAN CONSTRUCTION AND DEMOLITION DEBRIS MANAGEMENT
items: The Role of Marketing in the Launch of New Products
items: Inclusive Sport and Education: Adapting Physical Activity for Children with Physical and Intellectual Disabilities
items: RISK MANAGEMENT IN INFRASTRUCTURE PROJECT PLANNING: METHODS AND PREVENTIVE STRATEGIES
items: MODERN TECHNOLOGIES AND TECHNIQUES OF MEGA HAIR FOR SENSITIVE SCALPS OR ABSENCE OF NATURAL HAIR
items: THERAPEUTIC MANAGEMENT OF CANINE LEPTOSPIROSIS: SUPPORTIVE PROTOCOLS AND ANTIBIOTIC THERAPY
items: THERAPEUTIC MANAGEMENT OF CHRONIC KIDNEY DISEASE IN DOGS: SUPPORTIVE STRATEGIES AND LONGEVITY
items: CHALLENGES AND ADVANCES IN CATTLE REPRODUCTIVE MANAGEMENT
items: MECHANIZED AND ROTARY SYSTEMS IN ROOT CANAL PREPARATION
items: STABILITY IN ORTHOGNATHIC SURGERY IN CLASS III PATIENTS
items: THERAPEUTIC APPROACH TO AMELOBLASTOMA: REHABILITATION PROTOCOLS AND RECURRENCE CONTROL
items: RADIOGRAPHIC DIAGNOSIS OF INTERNAL AND EXTERNAL ROOT RESORPTIONS
items: TREATMENT OF TRICHOMONIASIS: CLINICAL MANAGEMENT AND IMPACT ON WOMEN’S HEALTH
items: THERAPEUTIC APPROACH TO UREMIC PERICARDITIS
items: MANAGEMENT OF CONGENITAL HEARING LOSS: EARLY INTERVENTION STRATEGIES
items: THERAPEUTIC APPROACH TO AGORAPHOBIA: PHARMACOLOGICAL AND COGNITIVE-BEHAVIORAL STRATEGIES
items: THERAPEUTIC MANAGEMENT OF DIABETIC POLYNEUROPATHY: FROM GLYCEMIC CONTROL TO PAIN MANAGEMENT

3D PRINTING AS A STRATEGIC TECHNOLOGY OF INDUSTRY 4.0: A SYSTEMATIC REVIEW OF THE MAIN APPLICATION AREAS
type: item
description: Three-dimensional printing (3D printing) is one of the key technologies of Industry 4.0, with increasingly diversified applications and significant impact on strategic sectors such as education, healthcare, engineering, sustainability, art. This article presents a systematic review of scientific literature published between 2020 and 2024, aiming to identify the main application areas of 3D printing and analyze the methodological and thematic contributions of the selected studies. The search was conducted in the Web of Science (WoS) database, using descriptors in Portuguese, English, and Spanish related to technology and its applications. After the screening and selection process, 26 articles were included in the qualitative analysis. Thematic categorization allowed for the organization of studies into seven main areas: education, engineering/industry, biomaterials/biofabrication, human health, veterinary health, energy/sustainability, and art and design. The results show a balanced distribution across fields, with emphasis on educational and industrial applications. The analysis was complemented by a comparative table and a word cloud, reinforcing the versatility and interdisciplinary nature of the technology. The evidence highlights the potential of 3D printing as an educational, technological, and socially transformative tool, especially when aligned with sustainable and accessible practices. This study contributes to understanding the strategic role of 3D printing in Industry 4.0, highlighting trends, gaps, and research opportunities aligned with the Sustainable Development Goals of the 2030 Agenda.
subject: Articles
  topic: section
subject: 3D Printing
  topic: keywords
subject: Industry 4.0
  topic: keywords
subject: Technological Applications
  topic: keywords
subject: Sustainability
  topic: keywords
subject: Innovation
  topic: keywords
creator: Arlindo Aparecido Zeferino
creator: Bárbara Alberta Lehner de Freitas
creator: Neiva Aparecida Pereira Lopes
creator: Luiz Henrique de Freitas Oliveira
creator: Kátia Eliane Santos Avelar
creator: Maria Geralda de Miranda
rights: Copyright (c) 2026 https://creativecommons.org/licenses/by-nc/4.0
date: 2026-02-19
publication date: 2026-02-19
starting page: e9410
ending page: e9410
doi: 10.56238/isevmjv5n1-025

THERAPEUTIC MANAGEMENT OF COLORECTAL CANCER IN THE ELDERLY: BALANCING EFFICACY AND TOLERABILITY
type: item
description: Colorectal cancer (CRC) is the third leading cause of malignant neoplasia and the second leading cause of global cancer mortality (Sun et al., 2024). Due to the epidemiological aspects of this neoplasm, being more prevalent at older ages, this article focuses on this population group. Considering the physiological and pathological changes of aging (senescence and frailty), the elderly population has gained prominence in the search for better methods to ensure earlier diagnosis, improved screening strategies, and innovative targeted therapies that provide greater tolerability for this age group during oncological treatment. It is known that this group is more vulnerable and presents a higher prevalence of comorbidities compared to others. This study aims to conduct a review of current evidence on improvements in diagnostic protocols, such as the incorporation of proteomic analysis combined with non-genetic and genetic risk factors (Elez et al., 2025), and in oncological targeted therapies, such as cetuximab, bevacizumab, and FOLFOX for CRCs with KRAS mCR and BRAF mutations (H. Ahn et al., 2024; Elez et al., 2025). The analysis of the results shows that when individualized beyond chronological age, there is a positive association between research and techno-pharmacological innovation, targeted therapies focusing on oncopathogenesis, new diagnostic predictors, and improvement in prognostic indicators for the studied population.
subject: Articles
  topic: section
subject: Colorectal Cancer
  topic: keywords
subject: Elderly
  topic: keywords
subject: Targeted Therapies
  topic: keywords
subject: BRAF Mutations
  topic: keywords
subject: KRAS Mutations
  topic: keywords
subject: Geriatric Oncology
  topic: keywords
creator: Fernando Malachias de Andrade Bergamo
creator: Ryan Rafael Barros de Macedo
creator: Maria Isabel de Sampaio Rabello
creator: Rodrigo Dias Ferreira
creator: Rosimeire Anesia de Jesus Teixeira
creator: Auryane Ferreira de Queiroz
creator: Livia Campi Merlo
creator: Gabriely Verônica dos Santos Roriz
creator: Helena Graziani de Conti
creator: Tatiane Ribeiro Garcia
creator: Vanessa Libia Santos Leal
creator: Ana Beatriz Bragheto Granvile
rights: Copyright (c) 2026 https://creativecommons.org/licenses/by-nc/4.0
date: 2026-02-14
publication date: 2026-02-14
starting page: e9381
ending page: e9381
doi: 10.56238/isevmjv5n1-024

TREATMENT OF PEDIATRIC CELIAC DISEASE: MONITORING GROWTH AND DEVELOPMENT
type: item
description: Celiac disease is a chronic inflammatory autoimmune disorder triggered by gluten ingestion in genetically predisposed individuals, with a significant impact on the pediatric population, particularly on growth and development. Gluten-induced enteropathy in childhood damages the small intestinal mucosa, causing malabsorption of essential nutrients and ultimately leading to growth failure, delayed puberty, and nutritional deficiencies. This study aims to discuss the therapeutic management of pediatric celiac disease, with an emphasis on monitoring growth and development as central components of treatment. It is a narrative literature review conducted through a search in the PubMed database using standardized descriptors and included publications from the last five years addressing celiac disease, childhood, diagnosis, and treatment. These findings reveal that the clinical presentation of celiac disease during childhood is heterogeneous, including gastrointestinal and extra-intestinal manifestations, which can delay diagnosis and affect growth. Early recognition, based on serological evidence and, when appropriate, duodenal biopsy, is crucial for the effective implementation of a gluten-free diet, the only treatment currently proven effective. Strict adherence to the diet is also a key factor leading to clinical, nutritional recovery and catch-up growth, particularly in the initial months after diagnosis. However, the challenges associated with dietary adherence further emphasize the need for multidisciplinary follow-up. Systematic monitoring of growth, pubertal development, nutritional status, and serology is an essential aspect of the clinical management of pediatric celiac disease and is crucial for a favorable prognosis and the prevention of short- and long-term complications.
subject: Articles
  topic: section
subject: Celiac Disease
  topic: keywords
subject: Pediatrics
  topic: keywords
subject: Gluten-Free Diet
  topic: keywords
subject: Growth and Development
  topic: keywords
subject: Diagnosis
  topic: keywords
creator: Danielle Larissa Godinho Miranda
creator: Ryan Rafael Barros de Macedo
creator: Gabrielle Alves Goto
creator: Enzo Mugayar Campanholo
creator: Camilly Agra Moreira Ramos
creator: Juliana de Mattos Palhares Silva
creator: Letícia de Souza de Azevedo
creator: Júlia Sousa Pantoja da Rocha
creator: Luisa Santório de Oliveira
creator: Amanda Dias Zanelli
creator: Giullia Emillie de Filgueira e Queiroz
creator: Maria Paula Malta Fonseca Lins
creator: Helena Graziani de Conti
rights: Copyright (c) 2026 https://creativecommons.org/licenses/by-nc/4.0
date: 2026-02-14
publication date: 2026-02-14
starting page: e9380
ending page: e9380
doi: 10.56238/isevmjv5n1-023

THERAPEUTIC MANAGEMENT OF DYSTHYMIA (PERSISTENT DEPRESSIVE DISORDER): LONG-TERM STRATEGIES AND REMISSION
type: item
description: Persistent Depressive Disorder (PDD), previously known as dysthymia, is characterized by a chronic, progressive, and often treatment-resistant course, associated with significant functional impairment and continuous reduction in quality of life. This study aimed to analyze contemporary therapeutic strategies for the management of dysthymia, with an emphasis on long-term approaches and factors associated with clinical and functional remission. It is a literature review conducted through searches in PubMed and the Virtual Health Library, covering studies published in the last five years, focusing on pharmacological, psychotherapeutic, neurobiological, and technological interventions related to PDD. The analyzed studies highlight that PDD involves neurobiological alterations in subcortical structures associated with motivation and the reward system, contributing to its chronicity and limited response to conventional antidepressants. In pharmacological management, favorable evidence has been observed for the use of bupropion, lamotrigine, and, in treatment-resistant cases, amantadine, indicating promising therapeutic alternatives. The combination of pharmacotherapy and psychotherapy, especially Cognitive-Behavioral Therapy, has demonstrated greater efficacy in reducing symptoms and preventing relapses. Furthermore, psychological interventions based on digital technology showed a positive impact on quality of life improvement and ongoing treatment support. It is concluded that the management of Persistent Depressive Disorder requires an integrated, longitudinal, and individualized approach that considers the neurobiological, psychosocial, and clinical aspects involved in the chronification of the disorder. The combination of targeted pharmacological interventions, structured psychotherapy, and digital technologies constitutes a relevant strategy to promote clinical stability, sustained remission, and reduction of the functional impact of PDD.
subject: Articles
  topic: section
subject: Persistent Depressive Disorder
  topic: keywords
subject: Dysthymia
  topic: keywords
subject: Therapeutic Management
  topic: keywords
subject: Remission
  topic: keywords
subject: Pharmacotherapy
  topic: keywords
subject: Psychotherapy
  topic: keywords
subject: Amantadine
  topic: keywords
subject: Chronic Apathy
  topic: keywords
creator: Yasmin Silveira Fonteles
creator: Ryan Rafael Barros de Macedo
creator: Luisa Sachetti Favretto Favretto
creator: Camilly Agra Moreira Ramos
creator: Maria Isabel de Sampaio Rabello
creator: Karina de Paiva Rodrigues
creator: Sarah Steffany Maia Coelho
creator: Julia Nascimento Araujo
creator: Rodrigo Dias Ferreira
creator: Miqueia Aurelia Vieira Diniz Dantas
creator: Maria Gianna de Lima Fernandes
creator: Gisele Soares de Souza
creator: Letícia de Souza de Azevedo
rights: Copyright (c) 2026 https://creativecommons.org/licenses/by-nc/4.0
date: 2026-02-14
publication date: 2026-02-14
starting page: e9379
ending page: e9379
doi: 10.56238/isevmjv5n1-022

THERAPEUTIC MANAGEMENT OF ACUTE TRAUMATIC BRAIN INJURY: RESUSCITATION AND NEUROPROTECTION PROTOCOLS
type: item
description: Moderate to severe traumatic brain injury (TBI) represents a critical global challenge, requiring accurate neuroprognostication to guide triage and decisions regarding withdrawal of life-sustaining therapy. Contemporary management emphasizes multimodal monitoring, in which invasive Intracranial Pressure (ICP) measurement is increasingly supplemented by Brain Tissue Oxygen Pressure (PbtO₂), a crucial marker of tissue hypoxia independently associated with unfavorable outcomes. In parallel, advances in serum biomarkers—particularly glial fibrillary acidic protein (GFAP), neurofilament light chain (NfL), and ubiquitin carboxy-terminal hydrolase L1 (UCH-L1)—allow assessment of injury severity and monitoring of clinical trajectory through minimally invasive methods. Established predictive models such as the IMPACT and CRASH scores demonstrate moderate reliability (with AUC values up to 0.85 for mortality in IMPACT), although the overall quality of evidence is often downgraded due to self-fulfilling prophecy bias and heterogeneity in functional outcome assessment. In the pediatric setting, injury-specific characteristics necessitate greater reliance on advanced Magnetic Resonance Imaging (MRI), in contrast to the predominant use of computed tomography (CT) in adults. The integration of these objective data is essential to guide acute interventions—including ICP management and the judicious use of hyperosmolar therapies—and to inform long-term rehabilitation planning. Predictors such as bilateral absence of pupillary reactivity are considered moderately reliable indicators of in-hospital mortality.
subject: Articles
  topic: section
subject: Traumatic Brain Injury
  topic: keywords
subject: Trauma
  topic: keywords
subject: Mortality
  topic: keywords
creator: Ryan Rafael Barros de Macedo
creator: Gabriel Barreiros Lapetina Andrade Santana
creator: Maria Larissa do Nascimento Melo
creator: Manuela Gomes Lupoli
creator: Henrique Morrison Murchie
creator: Rodrigo Dias Ferreira
creator: Camile Souza Cardoso
creator: Natiéli Taís Seleprin
creator: Flávio Henrique do Nascimento Reges
creator: Luiz Felipe Fernandes Caldas
creator: Kássia Aparecida Campos Garcia
creator: Nicoli Viana Alves
creator: Natália Nascimento Barbosa
creator: Júlia dos Santos Martins
rights: Copyright (c) 2026 https://creativecommons.org/licenses/by-nc/4.0
date: 2026-02-14
publication date: 2026-02-14
starting page: e9378
ending page: e9378
doi: 10.56238/isevmjv5n1-021

THERAPEUTIC MANAGEMENT OF MENOPAUSE: HORMONAL APPROACH AND NON-HORMONAL ALTERNATIVES
type: item
description: Menopause is a physiological milestone characterized by the loss of ovarian follicular activity, often associated with vasomotor symptoms (VMS) and genitourinary syndrome of menopause (GSM). Although Menopausal Hormone Therapy (MHT) is the most effective intervention for symptomatic relief and prevention of bone loss, its use is limited by contraindications in specific subgroups, such as breast cancer survivors and patients with a history of endometriosis, requiring individualized approaches. Diagnosis is clinical and retrospective, but Anti-Müllerian Hormone (AMH) is a sensitive biomarker of ovarian reserve, useful in predicting impending menopause, despite persistent inaccuracy in determining the exact timing. Advances in non-hormonal alternatives represent a promising frontier, including neurokinin receptor antagonists such as fezolinetant and elinzanetant for VMS, and topical therapies such as vaginal hyaluronic acid and laser (CO2 and Er:YAG) for GSM/vulvovaginal atrophy, which demonstrate comparable efficacy in patient-centered outcomes, with favorable safety profiles for patients at oncologic risk. In addition, MHT has been shown to optimize weight loss response when combined with GLP-1 agonists such as semaglutide. However, therapeutic management of menopause still lacks long-term data regarding the cardiovascular, skeletal, and oncologic safety of new non-hormonal therapies, reinforcing the need for prospective studies to consolidate safe and individualized strategies during the climacteric period.
subject: Articles
  topic: section
subject: Menopause
  topic: keywords
subject: Hormone Therapy
  topic: keywords
subject: Non-Hormonal Alternatives
  topic: keywords
subject: Vasomotor Symptoms
  topic: keywords
subject: Genitourinary Syndrome of Menopause
  topic: keywords
subject: Anti-Müllerian Hormone
  topic: keywords
creator: Ryan Rafael Barros de Macedo
creator: Fernando Malachias de Andrade Bergamo
creator: Júlia Abel Cenci Guimarães
creator: Lorena Raquel Menezes dos Reis Silva
creator: Maria Isabel de Sampaio Rabello
creator: Vitória Xavier Tracierra
creator: Samara Vasconcelos Pereira
creator: Angélica Santana Ferreira
creator: Rodrigo Dias Ferreira
creator: Maria Katarina Araújo Souza Silva
creator: Mariana Aquino Zanotti
creator: Maria Gianna de Lima Fernandes
creator: Júlio César Alcantara de Deus
creator: Júlia dos Santos Martins
creator: Rosimeire Anesia de Jesus Teixeira
rights: Copyright (c) 2026 https://creativecommons.org/licenses/by-nc/4.0
date: 2026-02-14
publication date: 2026-02-14
starting page: e9377
ending page: e9377
doi: 10.56238/isevmjv5n1-020

THERAPEUTIC MANAGEMENT OF VASOSPASTIC ANGINA: STABILIZATION STRATEGIES AND ANTITHROMBOTIC THERAPY
type: item
description: Vasospastic angina (VSA) is a clinically relevant entity within the spectrum of ischemic syndromes with non-obstructive coronary arteries, characterized by transient vasoconstriction of the epicardial and/or microvascular coronary bed, with variable ischemic repercussions. Although often associated with chest pain at rest and transient electrocardiographic changes, its presentation may mimic acute coronary syndromes and culminate in malignant arrhythmias, myocardial infarction, and sudden death. Diagnosis remains challenging, particularly when coronary angiography does not reveal significant lesions, requiring high clinical suspicion and, in selected centers, provocative testing with acetylcholine and/or ergonovine. In treatment, calcium channel blockers constitute the therapeutic cornerstone, with nitrates as adjunctive agents. Controversies persist regarding the role of antithrombotic therapies in VSA without obstructive atherosclerosis, especially concerning the routine use of aspirin. Recent evidence reinforces the importance of a guided approach incorporating assessment of vasomotor dysfunction and inflammatory biomarkers, as well as potential genetic implications. This narrative review synthesizes contemporary evidence on diagnosis, first-line therapies, the rationale and limitations of antithrombotic use, and the impact of inflammation on pathophysiology, pointing to future perspectives for more precise and individualized management.
subject: Articles
  topic: section
subject: Vasospastic Angina
  topic: keywords
subject: Coronary Vasoconstriction
  topic: keywords
subject: Calcium Channel Blockers
  topic: keywords
subject: Antithrombotic Therapy
  topic: keywords
subject: Provocative Testing
  topic: keywords
subject: Inflammation
  topic: keywords
creator: Maria Clara Candeira Cardoso
creator: Ryan Rafael Barros de Macedo
creator: , Fernando Malachias de Andrade Bergamo
creator: Gabriel Barreiros Lapetina Andrade Santana
creator: Bernardo Bertoldo de Araujo
creator: Marcus Eduardo de Jesus Oliveira
creator: Judh Beatriz Trindade Gouveia dos Santos
creator: Manuela Gomes Lupoli
creator: Fernando Aparecido Rubio Domingues
creator: Rodrigo Dias Ferreira
creator: Henrique Morrison Murchie
creator: Júlio César Alcantara de Deus
creator: Rosimeire Anesia de Jesus Teixeira
rights: Copyright (c) 2026 https://creativecommons.org/licenses/by-nc/4.0
date: 2026-02-14
publication date: 2026-02-14
starting page: e9376
ending page: e9376
doi: 10.56238/isevmjv5n1-019

MAXILLARY SINUS LIFT TECHNIQUES: INDICATIONS AND CRITERIA FOR REHABILITATION OF ATROPHIC MAXILLAE
type: item
description: The present study consists of a narrative literature review aimed at discussing maxillary sinus lift techniques, their clinical indications, and the criteria for rehabilitation of atrophic maxillae. Tooth loss in the posterior maxillary region, combined with maxillary sinus pneumatization, results in insufficient bone volume for implant placement, making sinus floor elevation a fundamental and predictable surgical technique. The methodology was based on a search in the PubMed database, selecting articles published in the last five years in Portuguese and English. The results indicate that the choice between the lateral window technique and the transcrestal approach should be based on residual bone height, with the lateral approach indicated for remnants smaller than 4 to 5 mm. Technological advances are highlighted, particularly the osseodensification technique and the use of piezoelectric devices to reduce complications, such as perforation of the Schneiderian membrane. Regarding biomaterials, although autogenous bone remains the gold standard, xenografts and the use of platelet concentrates (L-PRF) show excellent results in accelerating new bone formation and healing. It is concluded that maxillary sinus lift is a safe procedure when preceded by careful three-dimensional planning, enabling satisfactory functional rehabilitation in patients with severe maxillary atrophy.
subject: Articles
  topic: section
subject: Maxillary Sinus Lift
  topic: keywords
subject: Dental Implants
  topic: keywords
subject: Biomaterials
  topic: keywords
subject: Atrophic Maxilla
  topic: keywords
creator: Sebastião Diogo Fiochi Almeida Matozo
creator: Dayvid de Sousa Santana Fernandes
creator: José Eduardo Tannuri Nemeth
creator: Giulia Dias Ribeiro
creator: Ivan Queiroz Montanha
creator: Hallef Rossetti da Silva
creator: Claudionor Ribeiro de Vasconcelos Ferreira Neto
creator: João Cavalcante da Silva
rights: Copyright (c) 2026 https://creativecommons.org/licenses/by-nc/4.0
date: 2026-02-14
publication date: 2026-02-14
starting page: e9375
ending page: e9375
doi: 10.56238/isevmjv5n1-018

THERAPEUTIC MANAGEMENT OF CHILDHOOD GINGIVITIS: MECHANICAL BIOFILM CONTROL PROTOCOLS AND ORAL HYGIENE
type: item
description: Biofilm-induced gingivitis is a common inflammatory condition in childhood, characterized by a reversible gingival response to the accumulation of bacterial plaque. Although it presents a local character, recent evidence indicates that childhood oral health may influence future systemic outcomes, reinforcing the importance of early preventive strategies. The present study aimed to discuss the main therapeutic management protocols for childhood gingivitis, with emphasis on mechanical biofilm control, oral hygiene interventions, and modulating factors associated with diet and socioeconomic context. This is a narrative literature review conducted in the PubMed database, including studies published over the last five years. The results demonstrate that interactive educational approaches, especially those mediated by digital tools and playful models, show greater effectiveness in reducing plaque and gingival bleeding indices compared to conventional verbal instructions. It was also observed that periodic professional follow-up and continuous motivation favor rapid clinical responses, with a significant reduction in inflammatory signs. Furthermore, appropriate dietary habits, with lower sugar consumption and higher intake of dairy proteins, contribute to the control of gingival inflammation. Family and socioeconomic factors also exert a relevant influence on adherence to preventive practices. It is concluded that the therapeutic management of childhood gingivitis should be multidimensional, integrating mechanical biofilm control, health education, nutritional guidance, and family involvement in order to promote oral health throughout childhood.
subject: Articles
  topic: section
subject: Gingivitis
  topic: keywords
subject: Child
  topic: keywords
subject: Oral Hygiene
  topic: keywords
creator: Maria Gabrielly Soares Evangelista
creator: Isabelle Domingues da Silva
creator: Maria Luiza do Nascimento Silva
creator: Apoliana Reis
creator: Junia Carolina Bicalho de Castro
creator: Ivan Sousa de Brito
creator: Giulia Dias Ribeiro
creator: Marya Rabechy Cavalcante de Araújo
rights: Copyright (c) 2026 https://creativecommons.org/licenses/by-nc/4.0
date: 2026-02-14
publication date: 2026-02-14
starting page: e9374
ending page: e9374
doi: 10.56238/isevmjv5n1-017

THERAPEUTIC MANAGEMENT OF ODONTOGENIC KERATOCYST: FROM SIMPLE ENUCLEATION TO ADJUVANT TECHNIQUES
type: item
description: Odontogenic Keratocyst (OKC) is a lesion of odontogenic origin recognized for its aggressive biological behavior and high recurrence rate, making its therapeutic management a significant clinical challenge. In this context, several surgical approaches have been proposed over time, ranging from conservative methods such as simple enucleation and marsupialization to more aggressive techniques associated with adjuvant treatments. This study aims to review the therapeutic management of OKC, analyzing the main surgical techniques currently employed and the most effective adjuvant methods in reducing recurrence rates. The literature demonstrates that simple enucleation is associated with higher recurrence rates. On the other hand, the association of enucleation with adjuvant techniques such as peripheral ostectomy, chemical cauterization with Carnoy’s solution, and cryotherapy with liquid nitrogen has proven to be more effective in eliminating epithelial remnants and satellite cysts, significantly reducing lesion recurrence and providing better clinical outcomes.
subject: Articles
  topic: section
subject: Odontogenic Keratocyst
  topic: keywords
subject: Therapeutic Management
  topic: keywords
subject: Enucleation
  topic: keywords
subject: Adjuvant Techniques
  topic: keywords
subject: Recurrence
  topic: keywords
creator: Caio Uriel Vinhote do Nascimento
creator: Swelen Silva Cysne Benevides
creator: Daniela de Fátima Rodrigues Kudo
creator: Nathan Rodrigues Souza
creator: Beatriz Nery Pinheiro Farias
creator: Isabela Prestes Rufino
creator: Giulia Dias Ribeiro
creator: Alice Maria Barbosa de Sousa
rights: Copyright (c) 2026 https://creativecommons.org/licenses/by-nc/4.0
date: 2026-02-14
publication date: 2026-02-14
starting page: e9373
ending page: e9373
doi: 10.56238/isevmjv5n1-016

BONE RECONSTRUCTION TECHNIQUES WITH AUTOGENOUS GRAFTS: INDICATIONS AND DONOR SITE SELECTION CRITERIA
type: item
description: The long-term viability of dental implants is intrinsically linked to the presence of robust bone support. In cases of tooth loss resulting in severe resorption, ridge reconstruction becomes an indispensable step, and autogenous grafting is widely recognized as the gold standard due to its biological triad: osteogenesis, osteoinduction, and osteoconduction. This narrative review examines contemporary bone reconstruction techniques and the criteria for donor site selection, based on evidence collected from the PubMed database over the past ten years. The data indicate that, in addition to traditional autologous bone, the use of processed dental tissues (such as dentin) has emerged as an alternative with high biocompatibility and low morbidity, delivering solid clinical outcomes. In the management of horizontal defects in esthetic areas, the combination of bone chips with cortical barriers has proven effective in minimizing postoperative discomfort without compromising volumetric gain. On the other hand, cases of greater structural complexity may still require harvesting from extraoral sites. In summary, the success of regeneration lies in the clinician’s ability to select the technique that best balances the patient’s volumetric demand with biological preservation, reaffirming the superiority of the individual’s own tissue in achieving high-quality and stable newly formed bone.
subject: Articles
  topic: section
subject: Autogenous Bone Graft
  topic: keywords
subject: Dental Implants
  topic: keywords
subject: Bone Reconstruction
  topic: keywords
subject: Donor Site
  topic: keywords
subject: Processed Human Dentin
  topic: keywords
creator: Sebastião Diogo Fiochi Almeida Matozo
creator: Dayvid de Sousa Santana Fernandes
creator: Mordecai Amado de Souza Ribeiro
creator: Paula Melissa Vasconcelos dos Santos
creator: Maria Eduarda Coutinho Figueirêdo de Araújo
creator: Ítalo Júnior Almeida Josias
creator: Camila Rocha Pinheiro
creator: Mel Vaz Curvo Brunswick
creator: Otávio Silveira Rizzi
rights: Copyright (c) 2026 https://creativecommons.org/licenses/by-nc/4.0
date: 2026-02-14
publication date: 2026-02-14
starting page: e9372
ending page: e9372
doi: 10.56238/isevmjv5n1-015

ENVIRONMENTAL RISK MANAGEMENT IN THE WORKPLACE: IDENTIFICATION AND MITIGATION OF ENVIRONMENTAL HAZARDS AFFECTING WORKER HEALTH AND SAFETY
type: item
description: Environmental risk management in the workplace plays a fundamental role in protecting worker health and ensuring safe and sustainable organizational operations. Occupational environments often expose workers to a wide range of environmental hazards, including chemical agents, physical stressors, biological contaminants, and ergonomic risks, which can lead to acute injuries, chronic illnesses, and reduced productivity. This article examines how environmental risks in the workplace can be systematically identified, assessed, and mitigated using evidence-based occupational health and safety practices. Emphasis is placed on hazard recognition, risk assessment methodologies, implementation of the hierarchy of controls, continuous environmental and health monitoring, and worker participation. By integrating proactive risk management strategies with regulatory compliance and organizational culture, workplaces can significantly reduce environmental health risks, enhance worker wellbeing, and improve overall safety performance.
subject: Articles
  topic: section
subject: Environmental Risk Management
  topic: keywords
subject: Occupational Health and Safety
  topic: keywords
subject: Workplace Hazards
  topic: keywords
subject: Risk Mitigation
  topic: keywords
subject: Worker Health
  topic: keywords
creator: Sheila Silva de Melo
rights: Copyright (c) 2026 https://creativecommons.org/licenses/by-nc/4.0
date: 2025-12-19
publication date: 2025-12-19
doi: 10.56238/isevmjv3n6-017

PROJECT MANAGEMENT IN FOREIGN TRADE SOFTWARE IMPLEMENTATIONS: APPLICATION OF THE PMI METHODOLOGY IN REGULATED ENVIRONMENTS
type: item
description: The implementation of foreign trade software projects occurs within highly regulated environments where technological, legal, and organizational complexities intersect. These projects require rigorous management practices to ensure compliance with customs regulations, operational continuity, and stakeholder alignment. This article analyzes the application of the Project Management Institute (PMI) methodology in foreign trade software implementations, emphasizing scope definition, risk management, schedule control, compliance governance, and stakeholder management. By applying structured project management processes, organizations can mitigate regulatory and operational risks, reduce implementation delays, and improve system reliability. The analysis demonstrates that integrating compliance requirements into project governance frameworks enhances both project performance and regulatory adherence. The findings highlight the relevance of PMI-based methodologies as strategic instruments for managing complex software projects in regulated international trade environments.
subject: Articles
  topic: section
subject: Project Management
  topic: keywords
subject: Foreign Trade Software
  topic: keywords
subject: PMI Methodology
  topic: keywords
subject: Regulated Environments
  topic: keywords
subject: Risk Management
  topic: keywords
subject: Compliance Management
  topic: keywords
subject: Stakeholder Management
  topic: keywords
creator: Diego Bassan Silva
rights: Copyright (c) 2026 https://creativecommons.org/licenses/by-nc/4.0
date: 2025-12-19
publication date: 2025-12-19
doi: 10.56238/isevmjv3n6-016

ENVIRONMENTAL IMPACTS OF DIFFUSE LOGISTICS IN URBAN CONSTRUCTION AND DEMOLITION DEBRIS MANAGEMENT
type: item
description: Urban construction and demolition (C&D) activities generate large volumes of debris that, when managed through fragmented and poorly coordinated logistics systems, produce significant environmental impacts. Diffuse logistics characterized by decentralized waste generation, informal transport, and irregular disposal pathways intensify greenhouse gas emissions, promote illegal dumping, and undermine material recovery and circular economy objectives. This article examines the environmental consequences associated with diffuse C&D waste logistics in urban contexts and discusses strategies through which cities can mitigate these negative effects. Drawing on academic literature and institutional reports, the analysis highlights the roles of regulatory frameworks, economic incentives, infrastructure investment, and social inclusion in improving environmental performance. The findings suggest that transforming diffuse waste flows into structured material management systems can substantially reduce emissions, conserve natural resources, and support sustainable urban development.
subject: Articles
  topic: section
subject: Construction and Demolition Waste
  topic: keywords
subject: Diffuse Logistics
  topic: keywords
subject: Urban Waste Management
  topic: keywords
subject: Environmental Impact
  topic: keywords
subject: Circular Economy
  topic: keywords
creator: Silton Luiz Pereira Proenca
rights: Copyright (c) 2026 https://creativecommons.org/licenses/by-nc/4.0
date: 2024-08-16
publication date: 2024-08-16
doi: 10.56238/isevmjv3n4-025

The Role of Marketing in the Launch of New Products
type: item
description: The launch of new products represents a critical stage in organizational growth and competitive strategy, as it determines market acceptance, brand positioning, and long-term performance. This article examines the role of marketing in the successful introduction of new products, emphasizing its strategic and operational contributions throughout the launch process. Drawing on established marketing theories and empirical studies, the discussion highlights how market research, segmentation, positioning, and integrated communication reduce uncertainty and enhance consumer adoption. In addition, the article reflects on professional experiences in product launch activities, illustrating how customer-oriented strategies, cross-functional coordination, and data-driven decision-making contribute to improved launch outcomes. The analysis demonstrates that effective marketing acts as a bridge between innovation and the market, transforming technical solutions into value propositions that resonate with consumers and support sustainable competitive advantage.
subject: Articles
  topic: section
subject: Product Launch
  topic: keywords
subject: Marketing Strategy
  topic: keywords
subject: Consumer Behavior
  topic: keywords
subject: New Product Development
  topic: keywords
subject: Market Adoption
  topic: keywords
creator: Andrea Valim Magalhães
rights: Copyright (c) 2026 https://creativecommons.org/licenses/by-nc/4.0
date: 2023-08-28
publication date: 2023-08-28
doi: 10.56238/isevmjv2n4-022

Inclusive Sport and Education: Adapting Physical Activity for Children with Physical and Intellectual Disabilities
type: item
description: Inclusive sport and physical education play a fundamental role in promoting equity, health, and social participation among children with physical and intellectual disabilities. Beyond physical benefits, inclusive sports environments foster psychosocial development, self-esteem, autonomy, and a sense of belonging. This article discusses inclusive approaches to working with children with disabilities in sport and physical education contexts, combining evidence from academic literature with reflective practice based on professional experience. Emphasis is placed on pedagogical flexibility, environmental adaptation, individualized instruction, and peer support as key strategies for ensuring meaningful participation. By adapting activities, communication methods, and learning expectations, educators and coaches can create inclusive spaces where children with diverse abilities are empowered to develop not only athletic skills but also personal and social competencies. The article argues that inclusive sport is not merely a technical adjustment, but an ethical commitment to diversity, dignity, and equal opportunity in childhood development.
subject: Articles
  topic: section
subject: Inclusive Sport
  topic: keywords
subject: Physical Education
  topic: keywords
subject: Children with Disabilities
  topic: keywords
subject: Adapted Physical Activity
  topic: keywords
subject: Inclusion
  topic: keywords
creator: Luis Eduardo Mello
rights: Copyright (c) 2026 https://creativecommons.org/licenses/by-nc/4.0
date: 2023-08-27
publication date: 2023-08-27
doi: 10.56238/isevmjv2n4-021

RISK MANAGEMENT IN INFRASTRUCTURE PROJECT PLANNING: METHODS AND PREVENTIVE STRATEGIES
type: item
description: Infrastructure projects are inherently exposed to a wide range of uncertainties due to their scale, complexity, long execution periods, and significant financial and social impacts. In this context, risk management plays a critical role in supporting effective planning and decision making, contributing to improved project performance and resilience. This article examines risk management in the planning of infrastructure projects, with a focus on systematic risk identification, qualitative and quantitative risk analysis, and the development of preventive and mitigation strategies. By integrating structured methodologies and analytical tools into the planning phase, project teams can better anticipate potential disruptions, allocate resources more efficiently, and reduce the likelihood and impact of adverse events. The discussion highlights the importance of proactive risk management practices in enhancing cost and schedule predictability, strengthening stakeholder confidence, and increasing the overall probability of project success in complex infrastructure environments.
subject: Articles
  topic: section
subject: Risk Management
  topic: keywords
subject: Infrastructure Projects
  topic: keywords
subject: Project Planning
  topic: keywords
subject: Qualitative Risk Analysis
  topic: keywords
subject: Quantitative Risk Analysis
  topic: keywords
subject: Risk Mitigation
  topic: keywords
creator: Caio César Souza Andrade
rights: Copyright (c) 2026 https://creativecommons.org/licenses/by-nc/4.0
date: 2023-01-20
publication date: 2023-01-20
doi: 10.56238/isevmjv2n1-034

MODERN TECHNOLOGIES AND TECHNIQUES OF MEGA HAIR FOR SENSITIVE SCALPS OR ABSENCE OF NATURAL HAIR
type: item
description: The advancement of mega hair technologies has increasingly incorporated dermatological and biomechanical principles to address the needs of individuals with sensitive scalps or partial to complete absence of natural hair. Traditional high-tension extension methods have been associated with follicular stress and traction-related alopecia, prompting the development of safer, low-tension alternatives. This article examines modern traction-free and scalp-preserving mega hair techniques, including tape-based systems, clip-in extensions, halo designs, micro-attachments, and lace-based hair prostheses. Emphasis is placed on mechanical load distribution, material biocompatibility, and biomimetic design as key factors in reducing dermatological risk while maintaining aesthetic realism. By integrating knowledge from cosmetology, dermatology, and material science, contemporary mega hair solutions offer improved comfort, safety, and inclusivity. The findings highlight the importance of individualized scalp assessment, professional application, and routine maintenance to ensure long-term scalp health and user well-being.
subject: Articles
  topic: section
subject: Mega Hair Technologies
  topic: keywords
subject: Sensitive Scalp
  topic: keywords
subject: Traction Alopecia
  topic: keywords
subject: Hair Prostheses
  topic: keywords
subject: Dermatological Safety
  topic: keywords
subject: Low-Tension Hair Extensions
  topic: keywords
creator: Jhenifer Monique Ku's Schmitt Chagas
rights: Copyright (c) 2026 https://creativecommons.org/licenses/by-nc/4.0
date: 2022-12-21
publication date: 2022-12-21
doi: 10.56238/isevmjv1n2-024

THERAPEUTIC MANAGEMENT OF CANINE LEPTOSPIROSIS: SUPPORTIVE PROTOCOLS AND ANTIBIOTIC THERAPY
type: item
description: Canine leptospirosis is a zoonotic disease with a global distribution, caused by pathogenic spirochetes of the genus Leptospira, presenting high clinical, epidemiological, and public health relevance. In dogs, it manifests in a multisystemic and clinically variable manner, often evolving to acute kidney injury and liver dysfunction. This work is a literature review aiming to discuss current antibiotic therapy and clinical support strategies in the therapeutic management of canine leptospirosis. The findings indicate that treatment should be initiated early, even in the clinical suspicion phase, with antibiotic therapy being essential for controlling bacteremia and eliminating renal colonization, associated with individualized supportive therapies according to the affected organs. It is highlighted that effective control of canine leptospirosis requires a multidisciplinary approach, well-established therapeutic protocols, and rigorous biosecurity measures, aiming at patient recovery and reducing the risk of zoonotic transmission.
subject: Articles
  topic: section
subject: Canine Leptospirosis
  topic: keywords
subject: Zoonoses
  topic: keywords
subject: Acute Kidney Injury
  topic: keywords
subject: Public Health
  topic: keywords
creator: Júlia Mayumi Imamura
creator: Maria Clara Pereira Roque
creator: Julia Pereira Bicalho
creator: Sheila Nogueira Saraiva da Silva
creator: Luana Bucher
creator: Lorrana Costa Santos
creator: Elise Vitória Leite Santos
creator: Luara Maria Lima Alberti
creator: Juliana da Silva Pessoa
rights: Copyright (c) 2026 Júlia Mayumi Imamura, Maria Clara Pereira Roque, Julia Pereira Bicalho, Sheila Nogueira Saraiva da Silva, Luana Bucher, Lorrana Costa Santos, Elise Vitória Leite Santos, Luara Maria Lima Alberti, Juliana da Silva Pessoa https://creativecommons.org/licenses/by-nc/4.0
date: 2026-01-30
publication date: 2026-01-30
starting page: e9204
ending page: e9204
doi: 10.56238/isevmjv5n1-014

THERAPEUTIC MANAGEMENT OF CHRONIC KIDNEY DISEASE IN DOGS: SUPPORTIVE STRATEGIES AND LONGEVITY
type: item
description: Chronic kidney disease (CKD) in dogs represents a substantial clinical challenge due to its progressive and irreversible evolution. Traditionally, therapeutic management is based on staging and controlling secondary complications such as hypertension, electrolyte disturbances, and intestinal dysbiosis. However, recent studies support multimodal approaches capable of directly interfering with the pathophysiological mechanisms that drive disease progression. In this scenario, the gut-kidney axis contributes to the morbidity and progression of CKD, becoming a fundamental therapeutic basis. The literature highlights that intestinal dysbiosis promotes the dysregulation of metabolic processes and systemic inflammation, favoring the accumulation of uremic toxins that exacerbate kidney damage. Therefore, strategic dietary management, with controlled protein restriction, increased fiber intake, and supplementation with essential amino acids, proves effective in modulating the microbiota, reducing the uremic load, and preserving lean mass. These strategies are complemented by intestinal microbiota replacement, adsorbents and vitamin D analogs for the control of secondary renal hyperparathyroidism, as well as individualized modulation of the renin-angiotensin-aldosterone system. In parallel, the application of sensitive biomarkers, such as symmetric dimethylarginine (SDMA), allows for early diagnosis and more rigorous monitoring of CKD progression. In short, the integration of personalized interventions is crucial to optimize survival and ensure the quality of life of canine nephropathic patients.
subject: Articles
  topic: section
subject: Biomarkers
  topic: keywords
subject: Lactobacillus acidophilus
  topic: keywords
subject: CKD (Chronic Kidney Disease)
  topic: keywords
creator: Júlia Mayumi Imamura
creator: Érica Nunes dos Santos
creator: Eliomar Oliveira da Silva
creator: Paula Rejane Leal Ferreira Ramos
creator: Gabryelle Pereira Alves da Silva
creator: Leonardo Costacurta
creator: Juliett Ribas Assis
creator: Thais de Moraes Silva
creator: Fernanda Araújo Gomes
rights: Copyright (c) 2026 Júlia Mayumi Imamura, Érica Nunes dos Santos, Eliomar Oliveira da Silva, Paula Rejane Leal Ferreira Ramos, Gabryelle Pereira Alves da Silva, Leonardo Costacurta, Juliett Ribas Assis, Thais de Moraes Silva, Fernanda Araújo Gomes https://creativecommons.org/licenses/by-nc/4.0
date: 2026-01-30
publication date: 2026-01-30
starting page: e9203
ending page: e9203
doi: 10.56238/isevmjv5n1-013

CHALLENGES AND ADVANCES IN CATTLE REPRODUCTIVE MANAGEMENT
type: item
description: Bovine reproduction is a fundamental pillar for the economic and productive viability of livestock farming; however, it faces challenges in fertility and genetic improvement due to low heritability in selection programs focused primarily on productivity. This results in undesirable genetic imbalances, directly impacting reproductive efficiency and animal welfare. This study aimed to review and analyze recent advances in the field, emphasizing the integration of genomics, physiology, and management. The methodology consisted of a literature review of articles published between 2020 and 2025 in the PubMed database. The analyzed studies demonstrate that, despite the low heritability of reproductive traits, consistent gains can be achieved through more refined and integrated selective strategies, especially with the identification of selection signatures associated with fertility, environmental adaptation, and productive longevity. Furthermore, the study highlights the relevance of including male fertility assessment and the use of digital monitoring technologies to support reproductive management. The results indicate that the application of genomic tools, combined with reproductive assessment and appropriate management, contributes to improving reproductive efficiency and the sustainability of bovine reproduction systems in modern animal production systems.
subject: Articles
  topic: section
subject: Genetic Improvement
  topic: keywords
subject: Genomics
  topic: keywords
subject: Animal Reproduction
  topic: keywords
subject: Monitoring Technologies
  topic: keywords
creator: Ana Edvirgens Vasconcelos de Souza
creator: Lucas Lobato Kalume Reis
creator: Leandro Giroux Gomes
creator: Eliomar Oliveira da Silva
creator: Hainoã Migdally Silva
creator: Lorrana Costa Santos
creator: Natalie Oliveira da Silva
creator: Átila Bonfim Ferreira Cavalcante
rights: Copyright (c) 2026 Ana Edvirgens Vasconcelos de Souza, Lucas Lobato Kalume Reis, Leandro Giroux Gomes, Eliomar Oliveira da Silva, Hainoã Migdally Silva, Lorrana Costa Santos, Natalie Oliveira da Silva, Átila Bonfim Ferreira Cavalcante https://creativecommons.org/licenses/by-nc/4.0
date: 2026-01-30
publication date: 2026-01-30
starting page: e9202
ending page: e9202
doi: 10.56238/isevmjv5n1-012

MECHANIZED AND ROTARY SYSTEMS IN ROOT CANAL PREPARATION
type: item
description: The biomechanical preparation of the root canal system is a fundamental step for the success of endodontic treatment, as it is directly related to the removal of microorganisms, organic tissues, and dentinal debris. With technological advances, mechanized and rotary nickel-titanium (NiTi) systems have assumed a central role in clinical practice, providing greater efficiency, predictability, and safety when compared to traditional manual instrumentation. The present study aims to review recent scientific literature on mechanized and rotary systems used in root canal preparation, discussing their characteristics, advantages, limitations, and association with irrigation protocols. This is a narrative bibliographic review conducted using the PubMed database, with the selection of articles published over the last five years. The analyzed studies demonstrate that mechanized systems promote better centering of canal preparation, reduction of procedural errors, and optimization of clinical time, especially in curved canals and those with complex anatomy. However, evidence indicates that no instrumentation technique is capable of reaching all root canal surfaces, making the association with chemical irrigants and activation methods indispensable. It is concluded that mechanized and rotary systems represent a significant advance in contemporary endodontics, provided they are used judiciously and integrated into effective irrigation protocols.
subject: Articles
  topic: section
subject: Endodontics
  topic: keywords
subject: Root Canal Preparation
  topic: keywords
subject: Mechanized Instrumentation
  topic: keywords
subject: Nickel-Titanium
  topic: keywords
creator: João Marcos Arruda Dassoler
creator: Matheus Prates Santos
creator: Bruna Queiroz da Silva Prates
creator: Fabio Luis Lopes de Oliveira
creator: Maria Julia Marques Cruz Bogéa
creator: Jennifer Alves Tomas
creator: Paula Loures Valle Lima
creator: Maria Luisa Silva de Melo
creator: Eduardo Loures Filho
creator: Lays Palmeira Veloso Loures
creator: Anna Julia Rosa Ferraz
creator: Isabella Pereira da Silva
rights: Copyright (c) 2026 https://creativecommons.org/licenses/by-nc/4.0
date: 2026-01-22
publication date: 2026-01-22
starting page: e9112
ending page: e9112
doi: 10.56238/isevmjv5n1-011

STABILITY IN ORTHOGNATHIC SURGERY IN CLASS III PATIENTS
type: item
description: Skeletal Class III malocclusion represents a complex dentofacial deformity characterized by discrepancies between the maxillary and mandibular skeletal bases, with significant aesthetic, functional, and psychosocial repercussions. In adult patients, bimaxillary orthognathic surgery has been widely recognized as the standard treatment for the definitive correction of these alterations; however, postoperative skeletal stability remains one of the main clinical challenges, as relapse may compromise the results achieved in the medium and long term. This study aimed to review recent literature on postoperative stability in Class III patients undergoing orthognathic surgery, with emphasis on factors associated with bone and condylar adaptation, three-dimensional planning, and clinical implications for maintaining outcomes. This is a narrative literature review based on studies published in recent years (2022 to 2025) addressing biomechanical, articular, and technological aspects related to orthognathic surgery. The findings demonstrate that bimaxillary surgery promotes significant improvements in facial aesthetics, skeletal symmetry, occlusion, and quality of life. Maxillary positioning and fixation show greater predictability compared to the mandible due to several factors. Postoperative stability is multifactorial and influenced by the magnitude of surgical movements, temporomandibular joint adaptation, neuromuscular response, and the use of three-dimensional virtual planning. Although the incidence of condylar resorption in Class III patients is lower than that observed in other skeletal deformities, this condition remains clinically relevant. It is concluded that bimaxillary orthognathic surgery, when properly indicated, planned, and performed, constitutes an effective and highly stable approach for the treatment of skeletal Class III, surpassing orthodontic camouflage in cases with significant skeletal discrepancy.
subject: Articles
  topic: section
subject: Orthognathic Surgery
  topic: keywords
subject: Class III Malocclusion
  topic: keywords
subject: Skeletal Stability
  topic: keywords
subject: Relapse
  topic: keywords
subject: Three-Dimensional Planning
  topic: keywords
subject: Temporomandibular Joint
  topic: keywords
creator: Murilo de Lorenzo
creator: Matheus Prates Santos
creator: Bruna Queiroz da Silva Prates
creator: João Vitor Palma Wilke
creator: Eduarda Alievi Xavier Meira
creator: Arthur Raphael Lopes Garcia
creator: Roberta Monteiro de Moraes
creator: Wendell Alencar dos Santos
creator: Jackeline Batista Leite
creator: Leonam Amadeu Pinheiro de Ataide
creator: Matheus Alves dos Santos
creator: Camila Eduarda Koehler Machado
rights: Copyright (c) 2026 https://creativecommons.org/licenses/by-nc/4.0
date: 2026-01-22
publication date: 2026-01-22
starting page: e9111
ending page: e9111
doi: 10.56238/isevmjv5n1-010

THERAPEUTIC APPROACH TO AMELOBLASTOMA: REHABILITATION PROTOCOLS AND RECURRENCE CONTROL
type: item
description: In the context of stomatology and head and neck surgery, ameloblastoma plays a prominent role. Although defined by the World Health Organization (WHO) as a benign entity, it exhibits biologically aggressive behavior, characterized by an infiltrative growth pattern and high recurrence rates, which demands an in-depth understanding of its pathogenic and clinical aspects to achieve a favorable prognosis. Ameloblastoma is an odontogenic neoplasm of epithelial lineage that, despite being histologically benign according to the WHO, displays a biological phenotype marked by aggressive medullary infiltration, progressive expansion, and elevated recurrence rates. The complexity of clinical management lies in the dichotomy between complete eradication of tumor margins and preservation of the functional and aesthetic integrity of the stomatognathic system. The analysis of contemporary therapeutic modalities indicates that the transition between conservative interventions and radical resections should be based on rigorous mapping of the histopathological subtype and the cortical extent of the lesion. In parallel, the integration of molecular biomarkers and immediate prosthetic reconstruction techniques redefines prognosis, enabling an approach that goes beyond strict oncological control. Clinical resolution and mitigation of tumor recurrence depend on individualized management, with particular attention to patient age and specific tumor biology. It is imperative that therapeutic outcomes be supported by longitudinal surveillance protocols and multidisciplinary rehabilitation, ensuring morphofunctional restoration and long-term preservation of quality of life.
subject: Articles
  topic: section
subject: Ameloblastoma
  topic: keywords
subject: Mandibular Neoplasms
  topic: keywords
subject: Local Recurrence
  topic: keywords
subject: Oral and Maxillofacial Surgery
  topic: keywords
subject: Oral Rehabilitation
  topic: keywords
creator: Wendell Alencar dos Santos
creator: Maria Laura dos Santos Silva
creator: Ana Carla Pimentel de Amorim
creator: Roberta Monteiro de Moraes
creator: Vicente Felizardo Souza Neto
creator: Murilo de Lorenzo
creator: Layse Doraci Carneiro da Silva
creator: Rafael Rodrigues de Siqueira
creator: Josafá Bernardo Lima Filho
creator: Giordanna Zanardi Passos
creator: Gustavo Henrique Amador Meloquero
creator: Yasmim Gonçalves Soares
rights: Copyright (c) 2026 https://creativecommons.org/licenses/by-nc/4.0
date: 2026-01-22
publication date: 2026-01-22
starting page: e9110
ending page: e9110
doi: 10.56238/isevmjv5n1-009

RADIOGRAPHIC DIAGNOSIS OF INTERNAL AND EXTERNAL ROOT RESORPTIONS
type: item
description: Root resorption corresponds to the progressive loss of mineralized dental tissues and may occur in a physiological, pathological, or idiopathic manner. This resorption can affect both the internal and external surfaces of the tooth, presenting different etiological mechanisms, radiographic patterns, and therapeutic implications. Early diagnosis is crucial for the prognosis of the dental element and for defining the most appropriate clinical approach; however, diagnosis often occurs sporadically during routine clinical and radiographic examinations, making a favorable prognosis more difficult. Conventional radiographs, such as periapical and panoramic images, are widely used as initial evaluation methods; nevertheless, because they are two-dimensional examinations, they present important limitations, including structural overlap, distortions, and low sensitivity for early lesions, with computed tomography being the most satisfactory examination for diagnosing this condition. This study is characterized as a narrative literature review, conducted through a systematized survey of scientific literature in the PubMed, Scopus, and Web of Science databases, using the descriptors “Tooth Resorption,” “Root Resorption,” “Radiography,” and “Diagnosis,” combined with Boolean operators; articles published in the last five years, available in full text and directly addressing the use of radiographic methods in the diagnosis of internal and external root resorptions were included, while duplicate studies, isolated case reports, and publications lacking methodological rigor were excluded. The selection process occurred in stages, including the reading of titles and abstracts and the critical analysis of full texts. The results demonstrate that Cone Beam Computed Tomography presents greater sensitivity and specificity compared to conventional radiographs, enabling detailed three-dimensional visualization, better differentiation between types of resorption, and volumetric analysis of…
subject: Articles
  topic: section
subject: Tooth Root Resorption
  topic: keywords
subject: Internal Root Resorption
  topic: keywords
subject: Cone Beam Computed Tomography
  topic: keywords
subject: Dental Radiography
  topic: keywords
creator: João Marcos Arruda Dassoler
creator: Maria Laura dos Santos Silva
creator: Maria Julia Marques Cruz Bogéa
creator: Jennifer Alves Tomas
creator: Paula Loures Valle Lima
creator: Maria Gabrielly Soares Evangelista
creator: Ytallo de Souza Martins
creator: Eduardo Loures Filho
creator: Arthur Akihiro Baba Pastana
creator: Héllen de Lacerda Oliveira
creator: Saulo Teixeira Duarte
creator: Cesar Jeremias dos Santos Junior
rights: Copyright (c) 2026 https://creativecommons.org/licenses/by-nc/4.0
date: 2026-01-21
publication date: 2026-01-21
doi: 10.56238/isevmjv5n1-008

TREATMENT OF TRICHOMONIASIS: CLINICAL MANAGEMENT AND IMPACT ON WOMEN’S HEALTH
type: item
description: Trichomoniasis, caused by the protozoan Trichomonas vaginalis, is one of the most prevalent non-viral sexually transmitted infections (STIs) worldwide, with serious repercussions for women’s health. This narrative review analyzes contemporary clinical management, highlighting changes in therapeutic guidelines in which the metronidazole regimen (500 mg, twice daily for 7 days) has demonstrated superiority over the single 2 g dose in reducing recurrence in women. Diagnosis has evolved with the consolidation of Nucleic Acid Amplification Tests (NAATs) as the gold standard, which are essential for identifying the approximately 85% of asymptomatic cases. The study addresses the epidemiological synergy between the parasite and increased susceptibility to HIV (a 50% increase in risk), mediated by inflammatory processes and damage to the epithelial barrier, as well as serious obstetric risks such as preterm birth and premature rupture of membranes. It is concluded that effective management requires the concomitant treatment of sexual partners through Expedited Partner Therapy (EPT) and systematic screening in vulnerable populations to interrupt the chain of transmission and mitigate reproductive harm.
subject: Articles
  topic: section
subject: Trichomonas vaginalis
  topic: keywords
subject: Trichomoniasis
  topic: keywords
subject: Metronidazole
  topic: keywords
subject: Women’s Health
  topic: keywords
subject: Vaginal Microbiota
  topic: keywords
subject: Sexually Transmitted Infections
  topic: keywords
creator: Ryan Rafael Barros de Macedo
creator: Amanda Peron Colassio
creator: Thamily de Oliveira Veiga
creator: Amanda Camilla Schmidt Bolzan
creator: Tais Araújo Silva Alves Penha
creator: Maria Angélica Bernardini Almeida de Oliveira
creator: Camilli dos Santos Nascimento
creator: Uslaene Rocha de Lima
creator: Elizandra Pereira Trindade
creator: Isadora Brasil Pessôa Zapparoli
creator: Morgana Ribeiro da Rocha
creator: Amanda Alves Alexandre
rights: Copyright (c) 2026 https://creativecommons.org/licenses/by-nc/4.0
date: 2026-01-19
publication date: 2026-01-19
starting page: e9061
ending page: e9061
doi: 10.56238/isevmjv5n1-007

THERAPEUTIC APPROACH TO UREMIC PERICARDITIS
type: item
description: Uremic pericarditis is an inflammatory condition affecting the pericardium in patients with severe renal dysfunction, particularly those with end-stage renal disease. Toxic metabolic byproducts accumulate in the bloodstream, triggering inflammation of this fibroelastic sac. Common clinical features include positional chest pain, a pericardial friction rub, and, in advanced cases, signs of cardiac tamponade. Uremic pericarditis is currently rare due to improved hemodialysis practices, but its decreasing frequency may contribute to delayed diagnosis. Early echocardiographic evaluation is essential in suspected cases to identify pericardial effusion or hemodynamic compromise. Although most patients improve with intensification of dialysis, some require surgical intervention, such as pericardiocentesis or the creation of a pericardial window, to relieve tamponade or obtain tissue for diagnostic purposes.
subject: Articles
  topic: section
subject: Uremic Pericarditis
  topic: keywords
subject: Hemodialysis
  topic: keywords
subject: Chronic Kidney Disease
  topic: keywords
subject: Cardiac Tamponade
  topic: keywords
subject: Uremic Toxins
  topic: keywords
subject: Pericardial Inflammation
  topic: keywords
creator: Lucas dos Anjos Seabra
creator: Ryan Rafael Barros de Macedo
creator: Yure Hermerson Pereira Lima
creator: Patrícia Natsumi Figueiredo Dohara
creator: Luis Alexandre Lago Marchesan
creator: Giovanna Lopes Evangelista
creator: Jose Wilson Alves de Menezes Filho
creator: Tais Araújo Silva Alves Penha
creator: Maria Angélica Bernardini Almeida de Oliveira
creator: Cecília Varchavsky de Moraes
creator: Uslaene Rocha de Lima
creator: Eduardo da Silva Chaves
rights: Copyright (c) 2026 https://creativecommons.org/licenses/by-nc/4.0
date: 2026-01-19
publication date: 2026-01-19
starting page: e9060
ending page: e9060
doi: 10.56238/isevmjv5n1-006

MANAGEMENT OF CONGENITAL HEARING LOSS: EARLY INTERVENTION STRATEGIES
type: item
description: Congenital hearing loss affects approximately 1 to 2 per 1,000 live births, with more than 50% of cases presenting a hereditary etiology. Early recognition of these causes, combined with effective neonatal hearing screening through Transient Evoked Otoacoustic Emissions (TEOAE) and Automated Auditory Brainstem Response (AABR), allows not only timely detection of hearing impairment but also etiological characterization, with a direct impact on therapeutic decision-making, functional prognosis, and family counseling. In this context, advances in molecular genetics and the development of gene therapies have emerged as promising perspectives for the future treatment of monogenic forms of congenital hearing loss (Mey et al., 2025; Lieu et al., 2020; Taylor et al., 2021). Without appropriate treatment, congenital hearing loss can lead to deficits in the development of communication, behavior, and intellect (Lieu et al., 2020; Zhang et al., 2025). Considering this, the identification of congenital hearing loss through Transient Evoked Otoacoustic Emissions (TEOAE) and Automated Auditory Brainstem Response (AABR) in neonatal hearing screening programs is crucial to initiate early rehabilitation with hearing aids or cochlear implants (Mey et al., 2025).
subject: Articles
  topic: section
subject: Congenital Hearing Loss
  topic: keywords
subject: Congenital CMV Infection
  topic: keywords
subject: Neonatal Screening
  topic: keywords
creator: Lucas dos Anjos Seabra
creator: Igor dos Santos Linhares
creator: Pedro Felipe Ferrari Silva
creator: Sthefanny Nunes Vieira
creator: Fernanda Gabrielle Ribeiro
creator: Francisco Breno Gomes Filgueiras
creator: Ingrid Faglioni Carbonera da Silva
creator: Yure Hermerson Pereira Lima
creator: Amanda Camilla Schmidt Bolzan
creator: Tais Araújo Silva Alves Penha
creator: Nathália Ayumi Yzuno Tamura
creator: Eduardo da Silva Chaves
creator: Cibele Aires Gonçalves
rights: Copyright (c) 2026 https://creativecommons.org/licenses/by-nc/4.0
date: 2026-01-19
publication date: 2026-01-19
starting page: e9059
ending page: e9059
doi: 10.56238/isevmjv5n1-005

THERAPEUTIC APPROACH TO AGORAPHOBIA: PHARMACOLOGICAL AND COGNITIVE-BEHAVIORAL STRATEGIES
type: item
description: Agoraphobia, currently recognized as an independent diagnostic entity, is characterized by intense fear and avoidance of situations in which escape is perceived as difficult or help unavailable. This disorder causes profound functional impairment, affecting approximately 2% of adolescents and presenting high rates of comorbidities and suicide risk. This narrative review analyzes recent scientific evidence on the management of agoraphobia, emphasizing the integration of pharmacotherapy and Cognitive-Behavioral Therapy (CBT). In the pharmacological domain, Selective Serotonin Reuptake Inhibitors (SSRIs) are established as first-line treatment, while the use of benzodiazepines should be restricted to the acute phase to avoid inhibition of therapeutic habituation. In the psychotherapeutic field, exposure techniques remain the gold standard, enhanced by technological innovations such as Virtual Reality Exposure Therapy (VRET) and self-guided digital interventions. The study also highlights the relevance of metacognitive beliefs in the maintenance of the disorder. It is concluded that a multidisciplinary and technologically integrated approach is essential to break the cycle of avoidance and promote sustained functional recovery.
subject: Articles
  topic: section
subject: Agoraphobia
  topic: keywords
subject: Cognitive-Behavioral Therapy
  topic: keywords
subject: Selective Serotonin Reuptake Inhibitors
  topic: keywords
subject: Virtual Reality
  topic: keywords
subject: Exposure
  topic: keywords
subject: Mental Health
  topic: keywords
creator: Priscila Mara Pereira Coradini
creator: Ryan Rafael Barros de Macedo
creator: Igor Alves Savi
creator: Anderson Ullisses Santana Soares
creator: Luiz Otávio da Silva Flor de Lima
creator: Silvana Costa Castro
creator: Matheus Oliveira de Azevedo
creator: Patrícia Natsumi Figueiredo Dohara
creator: Luis Alexandre Lago Marchesan
creator: Joana Paula Carvalho Correa
creator: Camilli dos Santos Nascimento
creator: Nailon de Morais Kois
creator: Darla Maria da Silva Lima
rights: Copyright (c) 2026 https://creativecommons.org/licenses/by-nc/4.0
date: 2026-01-19
publication date: 2026-01-19
starting page: e9058
ending page: e9058
doi: 10.56238/isevmjv5n1-004

THERAPEUTIC MANAGEMENT OF DIABETIC POLYNEUROPATHY: FROM GLYCEMIC CONTROL TO PAIN MANAGEMENT
type: item
description: Diabetic polyneuropathy (DPN) is the most common chronic complication of Diabetes Mellitus, affecting more than 50% of patients and severely impacting quality of life. This narrative review analyzes recent scientific evidence on the therapeutic management of DPN, ranging from pathophysiology to pain control. The pathogenesis is multifactorial, involving oxidative stress, advanced glycation, and microvascular dysfunction, which result in symmetric distal axonal damage (the “glove-and-stocking” pattern). Diagnosis remains essentially clinical, based on medical history and sensory testing using monofilaments and tuning forks. Therapeutic strategies are based on three pillars: strict metabolic control (glycemic and lipid), pathogenetic interventions (alpha-lipoic acid and benfotiamine), and management of neuropathic pain. For symptomatic relief, first-line agents such as pregabalin, duloxetine, and amitriptyline have demonstrated efficacy, with growing evidence (OPTION-DM study) supporting combination therapies for refractory cases. It is concluded that a multidimensional and individualized approach is essential to delay disease progression and reduce the risk of severe outcomes, such as ulcerations and amputations.
subject: Articles
  topic: section
subject: Diabetic Polyneuropathies
  topic: keywords
subject: Diabetes Mellitus
  topic: keywords
subject: Neuropathic Pain
  topic: keywords
subject: Glycemic Control
  topic: keywords
subject: Pregabalin
  topic: keywords
subject: Alpha-Lipoic Acid
  topic: keywords
creator: Uslaene Rocha de Lima
creator: Ryan Rafael Barros de Macedo
creator: Martina Bergmann Gross
creator: Patricia de Aguiar Marques
creator: Úrsula Cristina Cardoso Fontana
creator: Viviane Santos Ferreira
creator: Rafael da Rocha Dias Quintairos
creator: Rafael dos Anjos Seabra
creator: Rafael Marchioro
creator: Tainara do Nascimento Costa
creator: Joana Paula Carvalho Correa
creator: Yure Hermerson Pereira Lima
creator: Luis Alexandre Lago Marchesan
rights: Copyright (c) 2026 https://creativecommons.org/licenses/by-nc/4.0
date: 2026-01-19
publication date: 2026-01-19
starting page: e9057
ending page: e9057
doi: 10.56238/isevmjv5n1-003