THERAPEUTIC INTERVENTIONS IN THE TREATMENT OF MALIGNANT ACANTHOSIS NIGRICANS

Abstract

Malignant acanthosis nigricans (MNA) is a rare paraneoplastic syndrome, mainly associated with intra-abdominal adenocarcinomas. This study aimed to analyze the evidence on the therapeutic management of MNA and its relevance as a clinical marker of malignancy. A narrative review was conducted in the PubMed database, including articles published between 2016 and 2026 that addressed therapeutic interventions and clinical outcomes. The results demonstrate that the regression of skin lesions is directly related to the control of the underlying neoplasm, whether by surgical resection, chemotherapy, or targeted therapies. It was also observed that manifestations such as "tripe palms" may precede the oncological diagnosis, while the recurrence of lesions accompanies tumor progression. The absence of metabolic disorders and the abrupt onset of lesions reinforce the suspicion of malignancy. It is concluded that ANM acts as an important clinical and prognostic marker, and its early recognition is fundamental for the timely diagnosis and better therapeutic management of associated neoplasms.