INFLUENCE OF THE GUT MICROBIOTA ON ANTIMICROBIAL RESISTANCE IN KLEBSIELLA PNEUMONIAE

Abstract

Bacterial resistance has become one of the main challenges in contemporary health, especially when analyzed in conjunction with the gut microbiota and its interactions with antimicrobial therapies. This study aimed to analyze the relationship between the gut microbiota and the development of bacterial resistance. This is an integrative literature review, conducted in the PubMed/MEDLINE, SciELO, LILACS, and Google Scholar databases, including 15 articles selected according to criteria of relevance, timeliness, and suitability to the topic. The results indicate that, although the direct relationship between gut microbiota and bacterial resistance is not yet fully established, alterations in this ecosystem, such as dysbiosis associated with antibiotic use, favor the colonization and dissemination of resistant microorganisms, especially in hospital environments. It is concluded that the imbalance of the gut microbiota acts as a facilitating factor in the dynamics of bacterial resistance, highlighting the need for integrated therapeutic strategies that consider the regulation of the microbial ecosystem.