METABOLIC MECHANISMS OF TIRZEPATIDE IN ADIPOSE TISSUE REDUCTION AND AESTHETIC IMPLICATIONS

Abstract

The increasing prevalence of obesity and associated metabolic diseases represents a significant public health issue due to its clinical, metabolic, and aesthetic impacts. In this context, understanding the mechanisms involved in energy metabolism regulation and adipose tissue reduction becomes essential. Therefore, this study aimed to analyze the metabolic mechanisms of tirzepatide in reducing adipose tissue and its implications in the field of aesthetic biomedicine. This study is a qualitative literature review with a descriptive and exploratory approach, conducted through the analysis of scientific articles published in relevant health databases. Recent studies addressing the effects of tirzepatide on energy metabolism, adipose tissue, and metabolic outcomes were included. The results showed that tirzepatide acts through the activation of GIP and GLP-1 incretin receptors, promoting improved glycemic control, reduced food intake, and increased satiety. Additionally, the drug directly influences adipocyte metabolism by reducing lipid accumulation, modulating inflammatory processes, and enhancing fat utilization as an energy source. Improvements in insulin sensitivity and functional reorganization of adipose tissue were also observed. In conclusion, tirzepatide demonstrates high therapeutic potential in reducing adipose mass and regulating energy metabolism, with relevant impacts in both clinical and aesthetic contexts, standing out as a promising strategy for obesity treatment.