IMPACT OF CANNABIDIOL ON GUIDED BONE REGENERATION: IMPLICATIONS FOR MODERN IMPLANTODONTICS

Authors

  • Ariane Caroline Castro Alves
  • Tereza Regina Péres Vaz
  • José da Silva Júnior
  • Octávio Olivio Fuzzo
  • Eduardo Francisco de Souza Faco
  • Rhayara Pires Ferreira de Assunção
  • Beatriz Rezende de Oliveira
  • Larissa Ferreira Lourenço Auad
  • Tatiana Klein Alvaracci
  • Flavio Eduardo Brandão
  • Cecilia de Oliveira Costa Amorim
  • Giselle Amiska Soares
  • Adnaleila Silva de Medeiros Brandão
  • Guilherme Alchaar Sodré Duarte
  • Jennifer Vera Santos Gumert
  • Diego Barbosa da Silva
  • Julia de Araújo Koplowitz Bento
  • Roberto Gama de Oliveira
  • Marco Antonio Teixeira Candido

Keywords:

Cannabidiol, Guided Bone Regeneration, Implant Dentistry, Osteogenesis, Biomaterials

Abstract

Guided bone regeneration (GBR) is a widely used technique in implant dentistry to restore bone quantity and quality in areas with defects, aiming at implant success. In recent years, cannabidiol (CBD), a phytocannabinoid from Cannabis sativa, has shown promising therapeutic properties in regenerative processes due to its modulatory effects on inflammation, osteogenesis, and bone remodeling. This article presents a literature review of experimental and clinical studies on the effects of CBD on bone regeneration, analyzing its mechanisms of action, safety, efficacy, and potential applications in implant dentistry. Findings indicate that CBD promotes osteoblast differentiation, inhibits osteoclast activity, reduces inflammation, and enhances graft integration, creating a favorable environment for healing and implant success. Although results are promising, controlled clinical studies are needed to establish standardized therapeutic protocols and define safe doses. The incorporation of CBD in GBR represents an innovative perspective for personalized regenerative treatments, contributing to significant advances in modern implant dentistry.

DOI:https://doi.org/10.56238/sevened2025.031-032 

Downloads

Published

2025-09-19

Issue

Contemporary Dialogues in Health Sciences

Section

Articles

License

Copyright (c) 2025 Ariane Caroline Castro Alves, Tereza Regina Péres Vaz, José da Silva Júnior, Octávio Olivio Fuzzo, Eduardo Francisco de Souza Faco, Rhayara Pires Ferreira de Assunção, Beatriz Rezende de Oliveira, Larissa Ferreira Lourenço Auad, Tatiana Klein Alvaracci, Flavio Eduardo Brandão, Cecilia de Oliveira Costa Amorim, Giselle Amiska Soares, Adnaleila Silva de Medeiros Brandão, Guilherme Alchaar Sodré Duarte, Jennifer Vera Santos Gumert, Diego Barbosa da Silva, Julia de Araújo Koplowitz Bento, Roberto Gama de Oliveira, Marco Antonio Teixeira Candido

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

How to Cite

Alves, A. C. C. ., Vaz, T. R. P. ., da Silva Júnior, J. ., Fuzzo, O. O. ., de Souza Faco, E. F. ., de Assunção, R. P. F. ., de Oliveira, B. R. ., Auad, L. F. L. ., Alvaracci, T. K. ., Brandão, F. E. ., de Oliveira Costa Amorim, C. ., Soares, G. A. ., de Medeiros Brandão, A. S. ., Duarte, G. A. S., Gumert, J. V. S., da Silva, D. B., de Araújo Koplowitz Bento, J., de Oliveira, R. G. ., & Candido, M. A. T. . (2025). IMPACT OF CANNABIDIOL ON GUIDED BONE REGENERATION: IMPLICATIONS FOR MODERN IMPLANTODONTICS. Seven Editora, 498-514. https://sevenpubl.com.br/editora/article/view/8086