EFFECTS OF SGLT2 INHIBITORS ON GLYCEMIC CONTROL AND THE REDUCTION OF CARDIOVASCULAR AND RENAL OUTCOMES IN PATIENTS WITH TYPE 2 DIABETES: A BIBLIOGRAPHIC REVIEW

Abstract

The objective of this study was to identify the real effects of SGLT2 inhibitors and their efficacy on glycemic control and the impact of medication on the prevention of cardiovascular events and progression of diabetic kidney disease. To develop this research, a guiding question was developed: “What are the effects of SGLT2 inhibitors on glycemic control and cardiovascular and renal outcomes in patients with type 2 diabetes?”. The searches were performed in the PubMed Central (PMC) database. Four descriptors were used in combination with the Boolean term “AND”: SGLT2 inhibitors, Diabetes Mellitus Type 2, Cardiovascular Outcomes, Renal Protection. Thus, it is observed that SGLT2 inhibitors promote glycosuria, increase insulin sensitivity, in addition to reducing arterial stiffness, improving endothelial function, slowing the rate of decline in eGFR in diabetic patients, which allows us to conclude the effectiveness of their glycemic control effects, and reduction of cardiovascular and renal events in patients with type 2 diabetes mellitus.

DOI: https://doi.org/10.56238/sevened2025.036-092