A STUDY OF THE RELATIONSHIP BETWEEN CARBOHYDRATE RESTRICTION AND THE TREATMENT OF GLIOBLASTOMA: A LITERATURE REVIEW

Abstract

5 years of 5%. Because it is a difficult diagnosis to treat, it motivates several lines of research to optimize the currently proposed standard treatment, which consists of chemoradiation and surgical resection, when possible. The reduced use of the citric acid cycle and mitochondrial oxidative phosphorylation for energy production in cancer cells that primarily use anaerobic glycolysis, even in the presence of oxygen, characterizes the Warburg effect, which justifies the use of diets with restricted carbohydrate intake that generate ketosis to reduce energy intake and consequently delay tumor progression, since healthy cells are able to receive energy more efficiently from fatty acids. The conclusions of 21 articles selected from databases (PubMed and LILACS) related to diets with reduced carbohydrate intake and the treatment of glioblastoma were correlated, as well as seeking to analyze the secondary variables present in clinical studies. Thus, the complexity of conducting research on this topic becomes clear, and the need for more robust studies, especially clinical ones, is proposed to allow for a meta-analysis of the subject in order to define therapeutic approaches that may include or rule out the implementation of carbohydrate-restricted diets in the treatment of glioblastoma.

DOI: https://doi.org/10.56238/sevened2025.036-125