LEISHMANICIDAL INSIGHTS FROM PINE RESINE DERIVATIVES

Authors

  • Regis Silveira Barbosa
  • Ana Cláudia Cerqueira Oliveira
  • Mário Mateus Naves
  • Michelle de Aguiar Pimenta Julioti
  • Marília Vitória Franco da Silva
  • Carolina Ferreira Vaz
  • Laércio Couto
  • Herbert Júnior Dias
  • Lizandra Guidi Magalhães
  • Vladimir Constantino Gomes Heleno

Keywords:

Abietanes, Dehydroabietic Acid, Structural Modification, Biological Assays, Leishmania Amazonensis

Abstract

Due to the known potential of diterpenes to display biological activities, the aim of this work was to produce amide derivatives from dehydroabietic acid, naturally occurring in pine resins and evaluate them against Leishmania amazonensis. Our venture into the derivatives production led us to eight different amides which were properly identified and characterized by Nuclear Magnetic Resonance spectroscopy. Biological assays were carried out with all derivatives and the natural precursor against promastigote forms of L. amazonensis. Results show that two derivatives can be considered of better activity than the precursor against this parasite. This opens future perspectives to further explore that kind of diterpenes against Leishmania species.

DOI: https://doi.org/10.56238/sevened2025.036-144

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Published

2025-12-31

Issue

Expanded Science: Innovation and Research - 2° Edição

Section

Articles

License

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

How to Cite

Barbosa, R. S., Oliveira, A. C. C., Naves, M. M., Julioti, M. de A. P., da Silva, M. V. F., Vaz, C. F., Couto, L., Júnior Dias, H., Magalhães, L. G., & Heleno, V. C. G. (2025). LEISHMANICIDAL INSIGHTS FROM PINE RESINE DERIVATIVES. Seven Editora, 2797-2815. https://sevenpubl.com.br/editora/article/view/8867