BIOCOMPATIBILITY OF ALTICRN+SI3N4 PROSTHETIC COATING IN A SUBCUTANEOUS ANIMAL MODEL OF MICE

Abstract

Nanotechnology used as a coating for orthopedic, neurological, and dental implants is increasingly important for their fixation and durability. Biocompatibility with bone tissue is therefore essential. After evaluating the results through histological analysis of 46 subcutaneous tissue samples from mice with and without AlTiCrN+Si3N4 coating (Titanium Aluminum Nitride enveloped in a silicon nitride layer), it was found that eosinophilic infiltration, intensity of the inflammatory process, and infiltration by multinucleated giant cells showed no statistical difference between the two groups. Fibrosis was found in the coated group, which was 1.7 times greater (RR = 1.7, 95% CI = 0.83 to 3.7), and the presence of black granular pigment characterized wear, displacement, and/or corrosion of the coating in all samples. It is concluded that such material has no space to be used in nanotechnological coatings of metal implants.

DOI: https://doi.org/10.56238/sevened2025.037-016