POLYMORPHISM OF THE APO-A AND APO-B GENES AND THE LIPID PROFILE OF PATIENTS WITH COVID-19: AN INTEGRATIVE REVIEW

Authors

  • Anna Beatriz Oliveira da Silva
  • Dante Mafra Tourino Teixeira
  • Antonio Avelino Ferreira Soares
  • Larissa Sousa Silva Bonasser
  • Bruna Rodrigues Gontijo
  • Alexandre Sampaio Rodrigues Pereira
  • Linconl Agudo Oliveira Benito
  • Izabel Cristina Rodrigues da Silva

Keywords:

Apolipoprotein B, Apolipoprotein A-1, Obesity, COVID-19, Genetic Polymorphism

Abstract

Objective: to analyze the influence of polymorphisms of APOA and APOB genes with the lipid profile of patients with COVID-19.

Method: the research was carried out in the databases Scholar Google, Biblioteca Virtual em Saúde - BVS, Portal de Periódicos CAPES, and PubMed, using the descriptors "Apo-B polymorphism AND SARS-Cov-2 AND COVID-19" and "Apo-A polymorphism AND Covid-19". We selected studies from 2020 that were compatible with the objective of the study.

Results: an association was found between the polymorphism of Apo A-1 -75G/A (rs670) and lower levels of triglycerides (TG) in patients with COVID-19, whereas the polymorphism of Apo B (rs693) was associated with reduced levels of TG only when and codominance with SNP -75G/A (rs670).

Conclusion: the polymorphisms of Apo A-1 and Apo B play a significant role in the prognosis and development of COVID-19, added to this is of paramount importance the investment in studies for so, the development of new therapeutic intervention strategies based on the patient’s genetic profile, in order to optimize treatment and increase survival of individuals in a critical state.

DOI: https://doi.org/10.56238/sevened2025.037-032

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Published

2025-12-05

Issue

Contemporary Dialogues in Health Sciences - 2° Edição

Section

Articles

License

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

How to Cite

da Silva, A. B. O., Teixeira, D. M. T., Soares, A. A. F., Bonasser, L. S. S., Gontijo, B. R., Pereira, A. S. R., Benito, L. A. O., & da Silva, I. C. R. (2025). POLYMORPHISM OF THE APO-A AND APO-B GENES AND THE LIPID PROFILE OF PATIENTS WITH COVID-19: AN INTEGRATIVE REVIEW. Seven Editora, 458-474. https://sevenpubl.com.br/editora/article/view/8679