EFFICACY OF THE QDENGA VACCINE IN THE PREVENTION OF DENGUE: AN INTEGRATIVE REVIEW OF CLINICAL EVIDENCE

Abstract

Dengue is one of the most impactful arboviral diseases worldwide, characterized by increasing incidence and persistent challenges in epidemiological control. The Qdenga® (TAK-003) vaccine, developed by Takeda Pharmaceuticals, has emerged as a promising preventive alternative with the potential to broaden population protection against the four dengue virus serotypes. This study aimed to critically analyze the scientific evidence available on the clinical efficacy of the Qdenga® vaccine in dengue prevention through an integrative literature review. Data collection was performed in the PubMed, SciELO, LILACS, and Google Scholar databases, including publications from 2017 to 2025 in Portuguese, English, and Spanish. A total of 20 studies were selected, comprising clinical trials, systematic reviews, and epidemiological modeling studies. The results indicate an overall efficacy ranging from 70% to 84%, with a significant reduction in hospitalizations and a low incidence of severe adverse events. The vaccine showed higher effectiveness among previously exposed populations, maintaining a balanced immunogenic profile and adequate safety. It is concluded that Qdenga® (TAK-003) is a relevant and promising tool for global dengue control, and its implementation should be accompanied by continuous epidemiological surveillance and real-world effectiveness studies to consolidate its impact on public health.

DOI: https://doi.org/10.56238/sevened2025.037-026